Flexible and transparent implants for combined electro- and opto-physiology
To enable the recording of neural dynamics with different spatiotemporal resolutions, we developed transparent micro electrocorticography arrays (µECoGs) for chronic multimodal recordings in vivo, such as electrophysiology and functional neuroimaging methods. We developed µECoGs based on flexible parylene-C substrates with electrodes based purely on PEDOT:PSS, exhibiting the best trade-off of material and physical properties including robustness to photo-induced artifacts, transparency, and low impedances. Hence, transparent µECoGs allowed the creation of functional maps that correlate calcium dynamics from groups of neurons across brain regions or individual neurons, when using widefield or two-photon imaging, respectively, together with electrical readings of local field potentials (LFPs) at the surface of the brain cortex. Even more, such implants proved not only its multimodal potential but a chronic performance of up to four and half months in vivo.
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Publications:
Azobenzene-based optoelectronic transistors for neurohybrid building blocks, Corrado et al., Nature Communications 2023, https://doi.org/10.1038/s41467-023-41083-2
Validation of transparent and flexible neural implants for simultaneous electrophysiology, functional imaging, and optogenetics, Koschinski et al., JMC B 2023, https://doi.org/10.1039/D3TB01191G
Pyramidal cell types drive functionally distinct cortical activity patterns during decision-making, Musall et al., Nature Neuroscience, 2023, https://doi.org/10.1038/s41593-022-01245-9
Aptamer based biosensor platforms for neurotransmitters analysis, Hu et al., Trend in Analytical Chemistry, https://doi.org/10.1016/j.trac.2023.117021
Highly Customizable 3D Microelectrode Arrays for In Vitro and In Vivo Neuronal Tissue Recordings, https://doi.org/10.1002/advs.202305944
Patents
- Viviana Rincón Montes, Simon Musall, Erkan Yilmaz, Sofiia Demchenko, and Andreas Offenhäusser. “Mehrsondensysteme für elektrogenes Gewebe, Verfahren zu deren Herstellung und Verwendungen”. Patent application: DE 102024110006.0, filed on April 10, 2024.
- Jamal Abu Shihada, Marie Jung, Lina Koschinski, Viviana Rincón Montes, and Andreas Offenhäusser. "Herstellung dreidimensionaler Elektroden mittels schablonengestützter elektrochemischer Abscheidung". Patent application: DE 102023102460.4, filed on February 1, 2023.
- Viviana Rincón Montes, Marie Jung, Jamal Abu Shihada, Lina Koschisnki, and Andreas Offenhäusser. "Herstellung dreidimensional strukturierter Elektrodenlagen, insbesondere im Kirigami-Prinzip". Patent application: DE 102023102257.1, filed on January 31, 2023.
Contact
Francesca Santoro
Forschungszentrum Jülich GmbH
E-Mail
